Preheat the oven to 375°F.

Line a baking sheet with parchment paper.

Season the tilapia fillets on both sides with the salt, pepper, garlic powder, and paprika. Arrange the fillets on the prepared baking sheet and spray lightly with nonstick cooking spray.

Bake the tilapia on middle rack of oven until the fillets are just opaque and flake easily with a fork, 7-9 minutes, depending on the thickness of the fillets.

Check to see that tilapia is done. Remove from oven or add time as needed.

Squeeze fresh lemon juice over the fillets and serve immediately.